Human trade and migration have homogenized the world such that every pest is everywhere -- bringing together organisms that normally would not meet and leading to catastrophic problems for agriculture. Learn how pests and disease cripple poor subsistence farmers, how global trade compounds this problem, and how agricultural universities such as Penn State contain the solutions. Presented by David Hughes on 11 February 2012 for the annual Penn State Lectures on the Frontiers of Science. To download the accompanying PowerPoint presentation, visit http://goo.gl/w4FXC. For more information, visit http://science.psu.edu/frontiers.