UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 17. Introduction to Chemical Biology -- Terpenes and Cell Signaling -- Part 1
View the complete course: http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.
License: Creative Commons BY-NC-SA
Terms of Use: http://ocw.uci.edu/info.
More courses at http://ocw.uci.edu
Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html
Recorded March 12, 2013.
Index of Topics:
Announcements
0:00:21- Week 10 Overview
0:00:41- Announcements
0:05:42- Office Hours
Lecture
0:06:34- Our Story to Date...
0:08:55- Biogenic head-To-Tail Synthesis of Terpenes
0:10:29- Mechanism for Head-To-Tail C-C Bond Formation
0:13:25- Some Common Linear Terpenes
0:14:41- Protein Prenylation: Localizes Protein to the Membrane
0:18:03- Bisphosphonates: Anti-Osteoporosis Drugs
0:20:27-The Rich Structural Diversity of Terpenes
0:21:35- Cyclization Cascades in Biosynthesis
0:23:29- Biosynthesis of Lanosterol
0:26:19- Humans Cannot Synthesize Retinoids
0:28:29- Dialing-In the Pink Color of Salmon
0:30:15- Non-Human Terpenes in Plants and Microorganisms
0:33:01- Reaction to Dye Brunette Hair Blonde Before the Invention of Hydrogen Peroxide
0:34:51- Cyclization of Isoprene Oligomers
0:39:51- Control Over the Central Dogma
0:42:22- Ancient Small Molecules with Bioactivity
0:44:53- Cell Signaling by Small Molecules
0:46:08- Arrows in Chemistry and Biology
0:49:11- Cell Signaling Scenarios
0:51:24- Spilling their Guts
0:52:28- Two Classes of Cell Signaling
0:53:11- Cell Signaling Involves 7 (seven) Possible Pathways
0:54:50- The 7 Signaling Pathways
0:56:16- Genetics to Dissect Complex Biology
0:58:21- Forward Chemical Genetics
1:01:06- Small Molecules Offer Control Over Otherwise Unavailable Phenotypes
1:02:16- High Thoughtput Small Molecule Screening
1:07:48- Nuclear Hormone Receptors
1:09:48- Estrogen Signaling
1:11:46- Retinoic Acid Signaling
1:13:16- Structure of a Nuclear Receptor Bound to DNA
1:15:10- Steroids Make Highly Potent Pharmaceuticals
1:16:57- Non-Steroidal Ligands to Nuclear Receptors
1:18:14- In Vivo Biosynthesis of Calcitriol
1:19:23- Restoring Biological Function of a Mutant Vitamin D Receptor
Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).
